African agriculture is at the crossroads. Persistent food shortages are now being compounded by new threats arising from climate change. But Africa faces two major opportunities that can help transform its agriculture and use it as a force for economic growth. First, advances in science and technology worldwide offer African countries new tools needed to promote sustainable agriculture. Second, efforts to create regional markets will provide new incentives for agricultural production and trade. This is the focus of the Agricultural Innovation in Africa (AIA) project. The project seeks to disseminate policy-relevant information on how to align science and technology missions with regional agricultural development goals. It does so in the context of the larger agenda to promote regional economic integration and development.